Guanylate cyclase 2C

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Aliases GUCY2C, DIAR6, GUC2C, MECIL, MUCIL, STAR, guanylate cyclase 2C
External IDs OMIM: 601330 MGI: 106903 HomoloGene: 3641 GeneCards: GUCY2C
Targeted by Drug
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 12: 14.61 – 14.7 Mb Chr 6: 136.7 – 136.78 Mb
PubMed search [2] [3]
View/Edit Human View/Edit Mouse

Guanylate cyclase 2C, also known as guanylyl cyclase C (GC-C), intestinal guanylate cyclase, guanylate cyclase-C receptor, or the heat-stable enterotoxin receptor (hSTAR) is an enzyme that in humans is encoded by the GUCY2C gene.[4][5]

Guanylyl cyclase is an enzyme found in the luminal aspect of intestinal epithelium and dopamine neurons in the brain.[6] The receptor has an extracellular ligand-binding domain, a single transmembrane region, a region with sequence similar to that of protein kinases, and a C-terminal guanylate cyclase domain. Tyrosine kinase activity mediates the GC-C signaling pathway within the cell.


GC-C is a key receptor for heat-stable enterotoxins that are responsible for acute secretory diarrhea.[7] Heat-stable enterotoxins are produced by pathogens such as Escherichia coli. Knockout mice deficient in the GC-C gene do not show secretory diarrhea on infection with E. coli, though they do with cholera toxin. This demonstrates the specificity of the GC-C receptor.

Diagnostic application[edit]

Because GC-C is tissue-specific for intestinal epithelium, it can be used for detection of metastatic disease.[citation needed][clarification needed]

See also[edit]


  1. ^ "Drugs that physically interact with Heat-stable enterotoxin receptor view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ "Entrez Gene: guanylate cyclase 2C (heat stable enterotoxin receptor)". 
  5. ^ Mann EA, Swenson ES, Copeland NG, Gilbert DJ, Jenkins NA, Taguchi T, Testa JR, Giannella RA (June 1996). "Localization of the guanylyl cyclase C gene to mouse chromosome 6 and human chromosome 12p12". Genomics. 34 (2): 265–7. doi:10.1006/geno.1996.0284. PMID 8661067. 
  6. ^ Intestinal Protein May Have Role in ADHD, Other Neurological Disorders. ScienceDaily (Aug. 11, 2011) [1]
  7. ^ Weiglmeier PR, Rösch P, Berkner H (August 2010). "Cure and Curse: E. coli Heat-Stable Enterotoxin and Its Receptor Guanylyl Cyclase C". Toxins. 2 (9): 2213–2229. doi:10.3390/toxins2092213. 

Further reading[edit]

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